Construction of 2‐(Trifluoromethyl)‐[1,2,4]Triazolo[1,5‐a]Quinoline Derivatives via Cycloaddition of N‐Amino Quinolinium Salts with CF3CN

Abstract A (3+2)‐cycloaddition of N ‐amino quinolinium salts with in situ generated trifluoroacetonitrile is disclosed. The reaction affords access to structurally diverse 2‐(trifluoromethyl)‐[1,2,4]triazolo[1,5‐ a ]quinoline derivatives in good yields, utilizing 2,2,2‐trifluoroacetaldehyde O ‐(aryl)oxime as precursor of trifluoroacetonitrile.