Diverse Cytokines Secreted by Adipocyte in Linking Cardio-Metabolic Disorder and SLE

脂肪因子 医学 胰岛素抵抗 代谢综合征 脂肪细胞 血脂异常 系统性红斑狼疮 脂肪组织 红斑狼疮 免疫学 内科学 疾病 肥胖 内分泌学 生物信息学 生物 抗体
作者
Min Lai,Kai‐Hsin Lin,Xiaofang Chen,Ye Cheng
出处
期刊:Frontiers in bioscience [IMR Press]
卷期号:29 (11)
标识
DOI:10.31083/j.fbl2911373
摘要

Systemic lupus erythematosus (SLE) is a multi-factorial autoimmune-mediated disease with hyper-stimulation of immune cells especially the T lymphocytes. By this method, it might facilitate the systematic damages in multiple tissues and organs. Otherwise, SLE is also correlated with diverse cardio-metabolic comorbidities, including dyslipidemia, insulin resistance, and hypertension. It is worth-noting that the risk of cardio-metabolic disorders is significantly higher compared with the healthy patients which was reported as approximately one-third of SLE patients were proved as obesity. Notably, current focus is shifting to implementing cardio-metabolic protective strategies as well as elucidating underlying mechanisms of lupus-mediated obese status. On the other hand, adipocyte, as the most abundant endocrine cell in fat tissue, are dysfunctional in obese individuals with aberrant secretion of adipokines. It is proposing that the adipokine might link the pathology of cardio-metabolic disorders and SLE, whereas the related mechanism is complicated. In the current review, the functions of adipokine and the potential mechanisms by which the adipokine link cardio-metabolic disorders and SLE was well listed. Furthermore, the recommendations, which identify the adipokine as the potential therapeutic targets for the treatment of cardio-metabolic disorders and SLE, were also summarized.
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