Altered effective connectivity in Parkinson’s disease patients with rapid eye movement sleep behavior disorder: a resting-state functional magnetic resonance imaging study and support vector machine analysis

The altered z-DC in the right precentral gyrus and the anomaly causal effects from the precentral motor cortex to the ipsilateral striatum represented by the caudate nucleus might play vital roles in the pathogenesis of PD-pRBD. It was speculated that the attenuation of FC from the precentral motor cortex to the subcortical striatum might be associated with nocturnal muscle dyskinesia and behavioral abnormalities in PD-pRBD patients. This disruption pattern may be a prospective imaging marker in the characterization of PD with pRBD.