Asymmetric synthesis of C–N axially chiral carbazoles via axial-to-axial chirality transfer

C-N axially chiral carbazole derivatives were synthesised by an intramolecular Buchwald-Hartwig amination starting from C-C axially chiral biaryls utilising an axial-to-axial chirality transfer with enantiospecificities up to 91%. The mechanism of the chirality transfer was investigated via DFT calculations.