Perioperative dynamic changes of systemic inflammatory response, gut injury, and hypoxemia in patients with acute type-A aortic dissection: an observational case-control study

Background: The details regarding the pathogenesis of hypoxemia in the presence of acute type-A aortic dissection (ATAAD) remains to be fully elucidated. In this study, we investigated the dynamic changes in systemic inflammatory response, gut injury, hypoxemia, and succinate levels in patients with ATAAD and their impact on perioperative hypoxemia. Methods: ratios were evaluated preoperatively and 4, 8, and 12 hours after operation. These variables were compared between different time points. Correlation analyses and multivariate linear regression were performed to evaluate the variables' impact on 12-hour postoperative hypoxemia. Results: ratio decreased significantly from the preoperative levels. Succinate levels peaked prior to the operation and remained elevated at both the 12- and 24-hour postoperative time points. PGN, iFABP, succinate, and lowest rectal temperature during cardiopulmonary bypass were the risk factors for hypoxemia at 12 hours' postoperation. Conclusions: Systemic inflammatory response, gut injury, and hypoxemia had already occurred preoperatively in patients with ATAAD and exacerbated postoperatively following TAR combined with FET procedure under hypothermic lower-body circulatory arrest and antegrade cerebral perfusion. Succinate may play a pivotal role in the development of hypoxemia in patients with ATAAD.