Catalytic Atroposelective Electrophilic Amination to Access Axially Chiral Diaryl Phenols

An enantioselective synthesis of axially chiral diaryl phenols containing sulfonamide groups has been achieved involving an electrophilic amination of 1,1'-biaryl-2,6-diols with N-sulfonyl quinone diimines, catalyzed by a chiral phosphoric acid. This atroposelective reaction offers a modular approach to enantiopure diaryl phenols, with good-to-excellent yields.