海马结构
小胶质细胞
星形胶质细胞
社会失败
海马体
胶质纤维酸性蛋白
心理学
社会压力
慢性应激
内分泌学
内科学
神经科学
中枢神经系统
医学
炎症
免疫组织化学
作者
Yingjuan Xu,Jiling Zhang,Florian Zeman,Handi Zhang
出处
期刊:Neuroreport
[Ovid Technologies (Wolters Kluwer)]
日期:2022-11-01
卷期号:33 (18): 828-834
被引量:1
标识
DOI:10.1097/wnr.0000000000001854
摘要
Adolescent social stress has been associated with the vulnerability to developing psychopathological disorders in adulthood that are accompanied by brain inflammatory processes. The purpose of this study is to investigate the dynamic changes of the hippocampal neuroinflammatory mediators, including microglia, astrocyte, and interleukin-6 (IL-6) levels in mice experiencing social defeat stress during adolescence. Adolescent mice were divided into the control group and stress group. Mice in the stress group were exposed to chronic intermittent social defeat for a total of 12 days, and control mice were reared in normal conditions. The hippocampal microglia, astrocyte, and IL-6 levels were measured 24 h and 3 weeks after the end of stress exposure. Microglia activation characterized by increased ionized calcium-binding adapter molecule 1 positive cell numbers or staining area in the CA1 and CA3 regions of the hippocampus were observed 24 h after the end of stress, which did not last into the adulthood. No short-term or long-term alterations of the number of hippocampal CA1 and CA3 glia fibrillary acidic protein astrocytes were found in mice experiencing adolescent social defeat, whereas IL-6 levels were only increased 3 weeks after the end of stress. These data suggested that exposure to chronic social defeat stress led to short-term and long-term neuroinflammatory changes in the hippocampus.
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