化学
纳米载体
壳聚糖
药物输送
核化学
共轭体系
结合
纳米颗粒
靶向给药
组合化学
纳米技术
有机化学
聚合物
材料科学
数学
数学分析
作者
Mozhgan Parsaei,Kamran Akhbari
出处
期刊:Inorganic Chemistry
[American Chemical Society]
日期:2022-11-16
卷期号:61 (48): 19354-19368
被引量:17
标识
DOI:10.1021/acs.inorgchem.2c03138
摘要
Herein, MOF-808 (MOF = metal–organic framework) based on zirconium tricarboxylate was synthesized to investigate the influence of decorating groups of folic acid-conjugated chitosan (CS-FA) on drug-delivery efficiency. Quercetin (QU) was loaded on nondecorated MOF-808 and then decorated with a folic acid–chitosan conjugate. The properties and activities of modified MOF-808 were compared with unmodified MOF-808. QU@MOF-808@CS-FA exhibited favorable drug-release properties, high drug-loading capacity, efficient targeting capability, and pH-dependent release behavior, highlighting the critical role of organic modification. A variety of characterization techniques were used to characterize MOF nanoparticles, including Fourier transform infrared, powder X-ray diffraction, field-emission scanning electron microscopy, energy-dispersive X-ray, transmission electron microscopy, Brunauer–Emmett–Teller, ζ potential, and 1H NMR. Additionally, Monte Carlo simulation calculations were carried out to examine the interactions between the structures of MOF-808 and QU. An in vitro cytotoxicity test was conducted, and the results identified that QU@MOF-808@CS-FA demonstrated more superior therapeutics than QU@MOF-808 on FR-positive MCF7 cancerous cells. On the basis of the results, QU@MOF-808@CS-FA is a promising drug carrier by selective targeting and sustained release.
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