层流
剪应力
内皮干细胞
流量(数学)
机械
材料科学
化学
生物物理学
细胞生物学
生物医学工程
体外
复合材料
生物
医学
物理
生物化学
作者
Jason Sedlak,Alisa Morss Clyne
出处
期刊:Methods in molecular biology
日期:2023-01-01
卷期号:: 81-90
标识
DOI:10.1007/978-1-0716-2851-5_5
摘要
Endothelial cell response to shear stress from the flowing blood plays an important role in diseases such as atherosclerosis. It is therefore essential to study how different flow regimes, including both atheroprotective laminar flow and atheropromoting disturbed flow, impact endothelial cell function. Shear stress effects can be studied in vitro using a variety of techniques, each with their own advantages and disadvantages. In this chapter, we describe how to use a parallel plate flow chamber to study the impact of both laminar and disturbed flow on endothelial cell monolayers.
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