Manganese self-boosting hollow nanoenzymes with glutathione depletion for synergistic cancer chemo-chemodynamic therapy

Metal nanoenzymes (HMnO 2 @CDDP) that can degrade to produce Mn 2+ exhibit Fenton-like, GSH-peroxidase-like activity. Treatment with nanoenzymes increased intratumor Pt-DNA content, leading to the up-regulation of γ-H2Aχ and an increase in tumor damage.