神经母细胞瘤
癌症研究
行动方式
医学
信号转导
放射治疗
免疫疗法
治疗方式
生物
生物信息学
药理学
免疫系统
内科学
免疫学
毒理
细胞生物学
遗传学
细胞培养
作者
Seyed Sajad Ahmadi,Omid Bagherzadeh,Meysam Sargazi,Farnaz Kalantar,Mohammad Amin Elahi Najafi,Mohammad Mahdi Vahedi,Amir R. Afshari,Amirhossein Sahebkar
摘要
Neuroblastomas are the most common solid tumors outside of the brain that originate from immature neural crest cells, accounting for about 10% of all pediatric malignancies. The treatment for neuroblastomas involves a multimodal schedule, including surgery, radiation, chemotherapy, and immunotherapy. All these modalities are limited by side effects that might be severe, poor prognosis, and a high risk of recurrence. In the quest for additional therapeutic approaches, phytochemicals have attracted attention owing to their reported antitumor properties, safety, and multimechanistic mode of action. Several studies have used plant-derived bioactive compounds such as phenolics and flavonoids, suggesting modulation of biomolecules and signal transduction pathways involved in neuroblastoma. We reviewed the findings of recent preclinical and clinical studies demonstrating the effects of phytochemicals on neuroblastoma, shedding light on their molecular mechanism of action and potential therapeutic applications.
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