败血症
医学
入射(几何)
感染性休克
社会经济地位
队列
生存分析
免疫学
内科学
重症监护医学
人口
环境卫生
物理
光学
作者
Kathryn L. Kapp,Albert B. Arul,Kevin C Zhang,Liping Du,Sachin Yende,John A. Kellum,Derek C. Angus,Octavia M Peck-Palmer,Renã A. S. Robinson
出处
期刊:Molecular omics
[The Royal Society of Chemistry]
日期:2022-01-01
卷期号:18 (10): 923-937
被引量:4
摘要
Intra-abdominal infection is a common cause of sepsis, and intra-abdominal sepsis leads to ∼156 000 U.S. deaths annually. African American/Black adults have higher incidence and mortality rates from sepsis compared to Non-Hispanic White adults. A limited number of studies have traced survival outcomes to molecular changes; however, these studies primarily only included Non-Hispanic White adults. Our goal is to better understand molecular changes that may contribute to differences in sepsis survival in African American/Black and Non-Hispanic White adults with primary intra-abdominal infection. We employed discovery-based plasma proteomics of patient samples from the Protocolized Care for Early Septic Shock (ProCESS) cohort (N = 107). We identified 49 proteins involved in the acute phase response and complement system whose expression levels are associated with both survival outcome and racial background. Additionally, 82 proteins differentially-expressed in survivors were specific to African American/Black or Non-Hispanic White patients, suggesting molecular-level heterogeneity in sepsis patients in key inflammatory pathways. A smaller, robust set of 19 proteins were in common in African American/Black and Non-Hispanic White survivors and may represent potential universal molecular changes in sepsis. Overall, this study identifies molecular factors that may contribute to differences in survival outcomes in African American/Black patients that are not fully explained by socioeconomic or other non-biological factors.
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