Peptide-coated, self-assembled M12L24 coordination spheres and their immobilization onto an inorganic surface

A nano-sized M12L24 coordination sphere coated with 24 hexapeptide aptamers (Arg–Lys–Leu–Pro–Asp–Ala: minTBP-1) was efficiently self-assembled from 12 Pd(II) ions and 24 bent ligands with minTBP-1 at their convex. The high density of aptamers covering the 3.5 nm diameter sphere resulted in irreversible immobilization on a Ti surface, in contrast to the relatively weak, reversible binding of a single aptamer.