对映选择合成
化学
索他洛尔
烷基化
醛
胺气处理
硝基醛反应
对映体
吡啶
催化作用
立体化学
有机化学
医学
心脏病学
心房颤动
作者
Gonzalo Blay,Víctor Hernández‐Olmos,José R. Pedro
标识
DOI:10.1016/j.tetasy.2010.02.027
摘要
A unified approach for the synthesis of (S)-(+)-sotalol and (R)-(−)-isoproterenol has been developed. The enantioselective Henry reaction of the appropriate aldehyde in the presence of a camphor-derived amino pyridine–Cu(II) complex was the key step of the synthesis. The reduction of the nitro group to give the corresponding amino alcohols followed by reductive alkylation of the amine provided the target products with high enantiomeric excesses.
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