Enantioselective synthesis of a 9,10-seco-taxane derivative via electrophilic epoxy-allylsilane ring closure

seco-Taxane 8, a potential starting material for further development into highly substituted taxanes, is synthesized by BF3·OEt2 treatment of epoxy-allylsilane 7, in its turn synthesized by joining an A-ring derivative 2 with a C-ring precursor chain 3.