声动力疗法
光热治疗
光敏剂
光动力疗法
乳腺癌
体内
生物医学工程
癌症研究
癌症
材料科学
纳米技术
医学
化学
内科学
生物
生物技术
有机化学
作者
Zhe Liu,Jiaping Li,Waner Chen,Lin Liu,Fangfang Yu
出处
期刊:Biomaterials
[Elsevier]
日期:2020-02-01
卷期号:232: 119685-119685
被引量:58
标识
DOI:10.1016/j.biomaterials.2019.119685
摘要
An ideal strategy to eliminate cancerous lesions is to implement light/sound as the most natural approaches, so that a non-invasive treatment can be realized to decrease the mortality and enhance the health quality of patients. Herein, the composite peptide amphiphile-ICG nanomicelles were fabricated via the self-assembly of engineered peptide amphiphiles in corporation with a sono-/photosensitizer of ICG encapsulation. As a multifunctional nanoagent, they were utilized to the SDT-PDT-PTT combination therapy, which proved prevailing efficiency for in-vitro cell targeting and in-vivo tumor treatments against breast tumors. The immune response activation mechanism on tumor inhibition and lesion necrosis were explained by routine blood examinations, pro-inflammatory cytokines analysis and histological HE-TUNEL stainings. In summary, this non-invasive strategy paves a promising way to the combination therapy against cancers, and it will be an extremely attracting approach for neuro-carcinomas and cerebral diseases treatments readily triggered by light/sound as an external controllable source.
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