丁香酚
医学
奥美拉唑
超氧化物歧化酶
生理盐水
药理学
病变
胃
胃肠病学
内科学
化学
病理
氧化应激
有机化学
作者
Bruna Longo,Ellen Perfoll Sommerfeld,Ana Caroline dos Santos,Rita de Cássia Melo Vilhena de Andrade Fonseca da Silva,Líncon Bordignon Somensi,Luísa Nathália Bolda Mariano,Thaise Boeing,Sérgio Faloni de Andrade,Priscila de Souza,Luísa Mota da Silva
标识
DOI:10.1016/j.cbi.2020.109335
摘要
This study evaluated the gastric healing activity of eugenol, the main bioactive compound from clove (Syzygium aromaticum) essential oil. Five groups of female Wistar rats were submitted to acetic acid-induced ulcer model and treated with Vehicle (1 ml/kg, p.o.), eugenol (1, 10 or 100 mg/kg, p.o) or omeprazole (20 mg/kg, p.o), twice a day, by seven or fourteen days. Macroscopic, microscopic, and biochemical analyses were performed in the ulcerated site. Eugenol (1 mg/kg, p.o) administered by 7 or 14 days accelerated the gastric healing process by 33% and 52%, respectively. The healing action of eugenol was accompanied by the rescue on the histological architecture and the normalization of the superoxide dismutase and catalase activity. Moreover, eugenol (1 mg/kg, p.o) reduced the gastric mucosal myeloperoxidase activity and increased the mucin secretion. In contrast, eugenol at a dose of 100 mg/kg administered by 7 days enhanced 49% the ulcerated area, but at 10 mg/kg did not change the ulcer area after 7 or 14 days of treatment. Thus, although the gastric healing potential of eugenol is evident, its administration needs to be manageable in an adequate dose due to the worsening of the gastric lesion with its use in high doses.
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