医学
肺结核
糖尿病
免疫学
结核分枝杆菌
免疫
免疫系统
获得性免疫系统
先天免疫系统
细胞免疫
疾病
内科学
病理
内分泌学
作者
Shoaib Rao,Maryam Rahim,Kiran Iqbal,Fatima Haroon,Zahra Hasan
出处
期刊:PubMed
日期:2019-01-01
卷期号:69 (1): 94-98
被引量:7
摘要
Tuberculosis (TB), caused by infection with mycobacterium tuberculosis, is a major source of morbidity and mortality in Pakistan. Diabetes caused by imbalance in glycaemic control is also highly prevalent in the country. The coincidence of both diseases results in worsening outcomes of TB, making treatment and management more difficult. Both innate and adaptive arms of the host immune response are required for protection against M. tuberculosis infection. Host immunity is modified in diabetes mellitus type 2 where key pathways such as, the T cell driven interferon-gamma responses to M. tuberculosis antigens and other T cell and macrophage activating cytokines are suppressed. This makes diabetes with TB a more severe disease and results in worse treatment outcomes. Effective coordination between T cells and host macrophages is required for control of TB infection. Therefore, early identification of diabetes and management of hyperglycaemia during TB treatment is essential for favourable outcomes.
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