超重
结直肠癌
肥胖
医学
疾病
老年学
癌症
病因学
入射(几何)
癌症预防
干预(咨询)
人口学
环境卫生
内科学
社会学
物理
光学
精神科
作者
Lucia Conti,Manuela Del Cornò,Sandra Gessani
标识
DOI:10.1016/j.critrevonc.2019.102834
摘要
Colorectal cancer (CRC) is a leading cause of cancer-related mortality in the world. Patterns and trends in CRC incidence and mortality correlate with increasing adoption of Western lifestyles and with the overweight/obesity epidemic. Both genetic background and a range of modifiable environmental/lifestyle factors play a role in CRC etiology. Among these the links of body weight, dietary patterns and physical activity (PA) behavior with CRC risk are some of the strongest for any type of cancer, with a different impact in women and men. Nonetheless, gender disparities still represent a neglected aspect of CRC management. This review sheds light on gender-related association of obesity and different dietary/PA habits with CRC risk, highlighting the importance of lifestyle modifications in the prevention of this neoplastic disease. In this scenario, intervention studies are strongly recommended to define the most effective dietary/PA regimens for primary prevention of cancer in women and men.
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