类风湿性关节炎
医学
免疫学
类风湿因子
自身免疫
免疫系统
疾病
关节炎
抗体
自身免疫性疾病
炎症
内科学
作者
Vivianne Malmström,Anca I. Catrina,Lars Klareskog
出处
期刊:Nature Reviews Immunology
[Springer Nature]
日期:2016-12-05
卷期号:17 (1): 60-75
被引量:310
摘要
Patients with rheumatoid arthritis can be divided into two major subsets characterized by the presence versus absence of antibodies to citrullinated protein antigens (ACPAs) and of rheumatoid factor (RF). The antibody-positive subset of disease, also known as seropositive rheumatoid arthritis, constitutes approximately two-thirds of all cases of rheumatoid arthritis and generally has a more severe disease course. ACPAs and RF are often present in the blood long before any signs of joint inflammation, which suggests that the triggering of autoimmunity may occur at sites other than the joints (for example, in the lung). This Review summarizes recent progress in our understanding of this gradual disease development in seropositive patients. We also emphasize the implications of this new understanding for the development of preventive and therapeutic strategies. Similar temporal and spatial separation of immune triggering and clinical manifestations, with novel opportunities for early intervention, may also occur in other immune-mediated diseases.
科研通智能强力驱动
Strongly Powered by AbleSci AI