Two new drimane sesquiterpenes from the endophytic fungus Curvularia tuberculata SC3295

Two new drimane sesquiterpenes curvudrimones A (1) and B (2) were isolated from the fermentation broth of an endophytic fungus Curvularia tuberculata SC3295 by silica gel, reversed phase silica column chromatography, Sephadex LH-20, and high-performance preparative liquid chromatography. The structures of the new compounds were characterised by extensive spectroscopic analyses (NMR and MS), ECD calculations, and single-crystal X-ray diffraction, enabling the assignment of the absolute configuration of compound 1. Moreover, compounds 1 and 2 were evaluated for cytotoxic, antibacterial, and antioxidant activities.