化学
细胞毒性
香豆素
赫拉
根茎
立体化学
苯醌
体外
顺铂
白花丹
细胞培养
传统医学
有机化学
植物
生物化学
遗传学
化疗
外科
生物
医学
作者
Hongwei Liu,Yisong Zhao,Rui‐Yun Yang,Meiqing Zheng,Manyuan Wang,Xue Zhang,Feng Qiu,Heng‐Shan Wang,Feng Zhao
标识
DOI:10.1002/hlca.200900172
摘要
Abstract Four new 1,4‐benzoquinone derivatives, belamcandaquinones J ( 1 ), K ( 2 ), L ( 3 ), and M ( 4 ), and one new coumarin, 5 , were isolated from the rhizome of Ardisia gigantifolia. Their structures were established by means of spectroscopic methods, and their cytotoxicity was tested in vitro against the cell lines PC‐3, EMT6, A549, Hela, RM‐1, and SGC7901. In comparison with cisplatin, compound 5 showed strong cytotoxicity with an IC 50 value of <30 μ M against the cell lines PC‐3 and A549. Compounds 1 – 4 showed no cytotoxicity against all cell lines.
科研通智能强力驱动
Strongly Powered by AbleSci AI