Development of an Efficient Process for 4,5,7-Trichloroquinoline, A Key Intermediate for Agrochemical Synthesis

A short, simple, and industrially feasible process for the preparation of 4,5,7-trichloroquinoline, starting from 3,5-dichloroaniline and acrylonitrile, in essentially three steps, is discussed. This article presents the preparative process, including the impurity profile, of each intermediate.