棕榈酰化
半胱氨酸
计算生物学
Gap-43蛋白
水准点(测量)
生物
刀切重采样
特征选择
计算机科学
生物化学
人工智能
酶
免疫组织化学
数学
大地测量学
估计员
免疫学
地理
统计
作者
Le-Le Hu,Sibao Wan,Shen Niu,Xiaohe Shi,Haipeng Li,Yu‐Dong Cai,Kuo‐Chen Chou
出处
期刊:Biochimie
[Elsevier]
日期:2011-03-01
卷期号:93 (3): 489-496
被引量:36
标识
DOI:10.1016/j.biochi.2010.10.022
摘要
Palmitoylation is a universal and important lipid modification, involving a series of basic cellular processes, such as membrane trafficking, protein stability and protein aggregation. With the avalanche of new protein sequences generated in the post genomic era, it is highly desirable to develop computational methods for rapidly and effectively identifying the potential palmitoylation sites of uncharacterized proteins so as to timely provide useful information for revealing the mechanism of protein palmitoylation. By using the Incremental Feature Selection approach based on amino acid factors, conservation, disorder feature, and specific features of palmitoylation site, a new predictor named IFS-Palm was developed in this regard. The overall success rate thus achieved by jackknife test on a newly constructed benchmark dataset was 90.65%. It was shown via an in-depth analysis that palmitoylation was intimately correlated with the feature of the upstream residue directly adjacent to cysteine site as well as the conservation of amino acid cysteine. Meanwhile, the protein disorder region might also play an import role in the post-translational modification. These findings may provide useful insights for revealing the mechanisms of palmitoylation.
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