泛连接蛋白
炎症体
细胞生物学
人口
生物
腹膜腔
免疫学
髓样
腹膜炎
炎症
微生物学
解剖
医学
细胞内
遗传学
缝隙连接
环境卫生
连接蛋白
作者
Hongbin Wang,Yue Xing,Liming Mao,Yi Luo,Lishan Kang,Guangxun Meng
出处
期刊:Protein & Cell
[Springer Nature]
日期:2013-04-01
卷期号:4 (4): 259-265
被引量:21
标识
DOI:10.1007/s13238-013-2114-1
摘要
Pannexin-1 (Panx1) forms nonselective large channel in cell plasma membrane and has been shown to be associated with NLRP3 inflammasome activation, ATP release and phagocytes recruitment. In the current study, by manipulation of Panx1 expression in human myeloid cells and application of Panx1 deficient mice, we failed to find a correlation between Panx1 and NLRP3 inflammasome activation, although an interaction between these two proteins was evident. However, in thioglycollate induced peritonitis, Panx1 deficient mice showed much more phagocytes infiltration. Further analyses showed that mice deficient for Panx1 exhibited enlarged F4/80(low)Gr1(-)Ly6C(-)cell population in the peritonea. Our study thus reveals an important role for Panx1 in regulation of peritoneal cell population and peritonitis development.
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