Radiologic evaluation of the patient with soft tissue sarcoma may include conventional radiography, scintigraphy, ultrasonography (US), computed tomography (CT), and magnetic resonance (MR) imaging. The radiologist also plays a critical role in the evaluation of the patient with soft tissue sarcoma by guiding and performing aspiration biopsies. This review discusses the use of radiological techniques to evaluate the primary lesion and to detect recurrences. In adults, soft tissue sarcoma most commonly occurs in the extremities, and this review emphasizes the role of MR imaging in the pre- and post-treatment evaluation of extremity soft tissue sarcomas. The role of imaging studies in the evaluation of soft tissue sarcomas in the abdomen, thorax, and the head and neck region is also discussed.