<title>Development of an optical polarimeter for in-vivo glucose monitoring</title>

In our investigation, we present both multi-spectral in vitro and preliminary single wavelength in vivo results supporting the use of optical polarimetry as a potential non-invasive method for glucose sensing. The site utilized for our in vivo measurements is the anterior chamber of the eye in a rabbit model. The anterior chamber of the eye contains a relatively clear and minimal scattering fluid known as the aqueous humor. The glucose levels of the aqueous humor are correlated to those of blood, therefore providing a mechanism to indirectly estimate blood glucose levels. A device to effectively couple light through the anterior chamber is also presented. As for the in vitro experiments, a multi-spectral approach is demonstrated as a method to minimize prediction error when glucose is not the only optically active component that varies in concentration.