丘脑
脑形态计量学
神经科学
神经影像学
基于体素的形态计量学
形态分析
大脑大小
形态学(生物学)
心理学
感觉系统
生物
医学
磁共振成像
认知心理学
白质
放射科
遗传学
作者
Jikke T. Boelens Keun,Eva M. van Heese,Max A. Laansma,Cees J. Weeland,Niels T. de Joode,Odile A. van den Heuvel,Jari K. Gool,Selina Kasprzak,Joanna K. Bright,Chris Vriend,Ysbrand D. van der Werf
标识
DOI:10.1016/j.neubiorev.2021.09.044
摘要
The thalamus is a central brain structure crucially involved in cognitive, emotional, sensory, and motor functions and is often reported to be involved in the pathophysiology of neurological and psychiatric disorders. The functional subdivision of the thalamus warrants morphological investigation on the level of individual subnuclei. In addition to volumetric measures, the investigation of other morphological features may give additional insights into thalamic morphology. For instance, shape features offer a higher spatial resolution by revealing small, regional differences that are left undetected in volumetric analyses. In this review, we discuss the benefits and limitations of recent advances in neuroimaging techniques to investigate thalamic morphology in vivo, leading to our proposed methodology. This methodology consists of available pipelines for volume and shape analysis, focussing on the morphological features of volume, thickness, and surface area. We demonstrate this combined approach in a Parkinson's disease cohort to illustrate their complementarity. Considering our findings, we recommend a combined methodology as it allows for more sensitive investigation of thalamic morphology in clinical populations.
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