荟萃分析
中止
磁刺激
随机对照试验
萧条(经济学)
医学
刺激
脑刺激
重性抑郁障碍
经颅直流电刺激
置信区间
心理学
内科学
物理医学与康复
精神科
心情
宏观经济学
经济
作者
Yuki Matsuda,Ryuichi Yamazaki,Taro Kishi,Nakao Iwata,Masahiro Shigeta,Shinsuke Kito
出处
期刊:Neuropsychobiology
日期:2021-07-28
卷期号:81 (1): 60-68
摘要
Repetitive transcranial magnetic stimulation (rTMS) has been employed worldwide for therapy-resistant depression. The Food and Drug Administration has approved a number of therapeutic devices for treating major depressive disorder; however, no studies have examined the differences in efficacy and acceptability among commercially available stimulation devices. The aim of our study was to compare the efficacy and acceptability of 3 stimulation devices (NeuroStar, MagPro, and Magstim) for depressive disorders.Our study included 31 randomized sham-controlled trials of high-frequency rTMS included in the network meta-analysis by Brunoni. We calculated the risk ratio and 95% confidence intervals, comparing each device with sham for the endpoints of response rate, remission rate, and all-cause discontinuation. We then analyzed the differences among the devices in effect size for those endpoints.After determining the effect sizes for the endpoints, we found no statistically significant subgroup differences in the response rates, all-cause discontinuation, or remission rates among the devices (p = 0.12, p = 0.84, and p = 0.07, respectively).Our results suggest similar efficacy and acceptability for the 3 stimulation devices. Future studies need to perform head-to-head comparisons of the efficacy and acceptability of the stimulation devices for treating depression using the same stimulation protocols.
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