微气泡
分散性
微流控
回声
材料科学
超声波
对比度(视觉)
生物医学工程
粒径
超声造影
纳米技术
生物系统
分析化学(期刊)
化学
色谱法
声学
光学
物理
高分子化学
生物
医学
物理化学
作者
Uğur Soysal,Pedro Azevedo,Flavien Bureau,Alexandre Aubry,Márcio S. Carvalho,Amanda C. S. N. Pessoa,Lucimara Gaziola de la Torre,Olivier Couture,Arnaud Tourin,Mathias Fink,Patrick Tabeling
标识
DOI:10.1016/j.ultrasmedbio.2022.03.011
摘要
We succeeded in freeze-drying monodisperse microbubbles without degrading their performance, that is, their monodispersity in size and echogenicity. We used microfluidic technology to generate cryoprotected highly monodisperse microbubbles (coefficient of variation [CV] <5%). By using a novel retrieval technique, we were able to freeze-dry the microbubbles and resuspend them without degradation, that is, keeping their size distribution narrow (CV <6%). Acoustic characterization performed in two geometries (a centimetric cell and a millichannel) revealed that the resuspended bubbles conserved the sharpness of the backscattered resonance peak, leading to CVs ranging between 5% and 10%, depending on the geometry. As currently observed with monodisperse bubbles, the peak amplitudes are one order of magnitude higher than those of commercial ultrasound contrast agents. Our work thus solves the question of storage and transportation of highly monodisperse bubbles. This work might open pathways toward novel clinical non-invasive measurements, such as local pressure, impossible to carry out with the existing commercial ultrasound contrast agents.
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