Objective To observe the outcomes of anesthesia with target-controlled infusion(TCI) of propofol and remifentanel in the elderly undergoing gestroendoscopy.Methods A total of 200 patients aged more than 70 years old was equally assigned into two groups.Group T was given TCI with target concentrtions of propofol 0.5-1.8 μg/ml and remifentanel 0.5-1.0 ng/ml.Group P was conventionally injected propofol 1.5-2.0 mg/kg,which was followed by 4 mg/s and supplemental injection of propofol if necessary.SBP,DBP,HR,RR and SpO2 were monitored.Propofol consumption and awakening time were compared.Results Anesthesia was more stable in group T than that in group P.Propofol consumption was less in group T than that in group P [(61.5±21.3) mg vs.(98.4±31.2) mg] and awakening time was earlier in group T than that in group P[(62±38) s vs.(426±57) s](P0.05).There was no case with severe respiratory depression in both groups.ConclusionCompared to propofol alone,anesthesia with TCI of propofol and remifentanel is better with less requirement of propofol and earlier awakening after surgery in the elderly undergoing gestroendoscopy.