In this paper,flotation experiments for the calcite-rich fluorite ore from Guizhou province are introduced.The run-of-mine contains 28.05% CaF_2 and 18.45% CaCO_3.After the sulfides in the ore are removed,F_(910)is taken as gangue depressant and oleic acid as fluorite collector and the fluorite concentrate assaying over 98% CaF_2 can be obtained,with a recovery of CaF_2 over 82%