The novel bioadhesive drug de livery systems have become very promising because of their advantages in targeti ng, extended and controlled release. Of those, the lectin-mediated bioadhesive delivery system has specific targeting. And the particulate preparation can impr ove drug's stability and control drug release. The above two reasons cause the l ectin-mediated bioadhesive particulate preparation to gain the most extensive a ttention. The current reviews focus on the second-generation bioadhesive mechan isms, bioadhesive materials, influence factors, their applications and future tr ends.