Autophagy is the ubiquitous biological phenomena of biont under the normal and pathological situation, it has important role of skeletal muscle protein metabolism balance, oxidative stress removal, muscle fiber muscle fiber and metabolic waste removal. Skeletal muscle autophagy regulation use m70R as the main signaling pathway, p53 and FOXO as the assist signaling pathway regulation the skeletal muscle autophagy together. Therefore researches the signal transducing pathway of skeletal muscle autophagy regulation has the significance to improve the skeletal muscle efficiency and keep skeletal muscle homeostasis, and provides some references for the skeletal muscle autophagy, the treatment and prevention of skeletal muscle atrophy and the other related diseases.