Clinical efficacy of glucocorticoids in the treatment of severe community acquired pneumonia and its impact on CRP

Objective To observe the clinical efficacy of glucocorticoids in the treatment of severe community acquired pneumonia(SCAP) and its impact on CRP.Methods 60 patients with SCAP were randomly divided into the treatment group and the control group.All patients were treated with the conventional therapy,and the treatment group was additionally treated with glucocorticoids.The level of CRP was detected before and after the treatment,and the clinical efficacy was evaluated 7 days after the treatment.Results The total effective rate was 83.3% in the treatment group,which was significantly higher than that in the control group(50.%) with significant difference(χ2 = 7.500,P 0.05).After the treatment,the level of CRP decreased more significantly in the treatment group than in the control group(P 0.05).The duration of hospital stay and re-infection rate decreased more obviously in the treatment group than in the control group(P 0.05).There was no serious adverse events in the two groups.Conclusion Glucocorticoids can significantly improve the clinical efficacy in the treatment of patients with SCAP,affect the release of CRP,and regulate inflammatory response.It is a safe and reliable method and worthy of widely clinical application.