Recent Advances in Peroxisomal Fatty Acid β-Oxidation

Besides mitochondria,peroxisomes are subcellular organelles that are capable of conducting β-oxidation of fatty acids in eukaryocytes.Peroxisomal fatty acid β-oxidation consists of four sequential enzymatic steps(oxidation,hydratation,dehydrogenation,and thiolytic cleavage),and results in the degradation of long-chain fatty acids or 2-methyl-branched fatty acids.In recent years,studies on peroxisomal fatty acid β-oxidation have become an active research focus,and substantial progresses have been made,especially for the metabolic enzymes.This article will review the recent advances in aspects of the functional characteristics,metabolic enzymes,regulation,and deficiencies of peroxisomal fatty acid β-oxidation.