The HMI (Human-Machine Interface) for the inverted vertical lathe was developed by using the Wincc Flexible software based on SIEMENS 840D CNC system. According to the Man-Machine engineering principles the interface factor and access level were arranged. And making use of this HMI (Human-Machine Interface) many useful functions including the touch screen can be realized. An example was given to demonstrate the HMI (Human-Machine Interface) design.