羰基化
化学
脱碳
格式化
芳基
卤化物
催化作用
钯
化学计量学
反应性(心理学)
甲酸甲酯
甲酸钠
氧化加成
有机化学
组合化学
光化学
药物化学
烷基
一氧化碳
替代医学
病理
医学
作者
Tsuyoshi Ueda,Hideyuki Konishi,Kei Manabe
出处
期刊:Organic Letters
[American Chemical Society]
日期:2012-09-28
卷期号:14 (20): 5370-5373
被引量:118
摘要
The high utility of 2,4,6-trichlorophenyl formate, a highly reactive and easily accessible crystalline CO surrogate, is demonstrated. The decarbonylation with NEt3 to generate CO proceeded rapidly at rt, thereby allowing external-CO-free Pd-catalyzed carbonylation of aryl/alkenyl halides and triflates. The high reactivity of the CO surrogate enabled carbonylation at rt and significantly reduced the quantities of formate to near-stoichiometric levels. The obtained trichlorophenyl esters can be readily converted to a variety of carboxylic acid derivatives in high yields.
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