Monoclonal antibodies : production, engineering, and clinical application

1. Introduction 2. Production of monoclonal antibodies 3. Antigen-antibody interactions: how affinity and kinetics affect assay design and selection procedures 4. The production and characterisation of synthetic peptide-derived antibodies 5. Human monoclonal antibodies 6. Bispecific monoclonal antibodies 7. The production of antibodies using phage display libraries 8. Genetic manipulation of monoclonal antibodies 9. Monoclonal antibodies in diagnostic immunoassays 10A. Monoclonal antibodies in diagnostic pathology 10B. In vivo targeting of monoclonal antibodies for immunoscintigraphy and therapy of human malignancies 11A. Monoclonal antibodies in infectious disease: diagnosis 11B. Monoclonal antibodies in the prophyllaxis and therapy of infectious disease 12A. Monoclonal antibodies in transplantation: immunohistology 12B. Monoclonal antibodies in transplantation: experimental studies on in vivo immunosuppression 12C. Monoclonal antibodies in transplantation: prophyllaxis of graft-versus-host disease after bone marrow transplantation 12D. Monoclonal antibodies in transplantation: use as therapeutic agents in clinical organ transplantation 13. Monoclonal antibodies and the skin 14. Monoclonal antibodies in endocrinology 15. Monoclonal antibodies in rheumatology 16. Technical appendix.