This paper reviewed the progress of probiotics biotransformation Chinese medicine in recent years. Study on the chemical composition of probiotic biological transformation of traditional Chinese medicine mainly focused on the content,structure modification of single component,producing active ingredients and content of effective ingredients. Biological activity of herbal extracts,single herb medicine and traditional Chinese medicine compound biotransformated by probiotics changed greatly. Probiotics biotransformation of Chinese medicine is becoming the effective way to study Chinese medicine innovation and modernization of traditional Chinese medicine.