Results of combined treatment of 48 colon cancer patients with metastases to the liver are analyzed. Efficacy of regional intraarterial chemoimmunotherapy with recombinant interleukine-2 (ronkoleukine) is evaluated. The results of the treatment demonstrate that regional intraarterial chemoimmunotherapy with recombinant interleukine-2 is a safe and promising method in combined treatment of advanced colon cancer, increases survival and improves quality of life.