脊髓损伤
神经科学
反射
反射亢进
脊髓
医学
免疫系统
心理学
免疫学
作者
Masaki Ueno,Yuka Ueno-Nakamura,Jesse Niehaus,Phillip G. Popovich,Yutaka Yoshida
摘要
Spinal cord injury (SCI) at high spinal levels (e.g., above thoracic level 5) causes systemic immune suppression; however, the underlying mechanisms are unknown. Here we show that profound plasticity develops within spinal autonomic circuitry below the injury, creating a sympathetic anti-inflammatory reflex, and that chemogenetic silencing of this reflex circuitry blocks post-SCI immune suppression. These data provide new insights and potential therapeutic options for limiting the devastating consequences of post-traumatic autonomic hyperreflexia and post-injury immune suppression.
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