Objective To study and compare the value of determination of tumor supplied group of factors(TSGF) in malignant solid tumors and hematological malignancy. Methods The serum levels of TSGF were detected in people with malignant solid tumors and in people with hematological malignancy and healthy controls respectively. Results The serum levels of TSGF in people with malignant solid tumors and in people with hematological malignancy are significantly higher than that in normal controls. Conclusion Determination of serum TSGF has significance in the study of malignant solid tumors and hematological malignancy.