Effects of Anti-"Oketsu"Drugs on Blood Coagulation and Fibrinolysis

Effects of three kinds of anti-"Oketsu"drugs, tohkaku-johki-toh, keishi-bukuryo-gan and tohki-shakuyaku-san, and twelve kinds of component crude drugs on blood coagulation-fibrinolysis system and platelet aggregation were investigated, and the following results were obtained. Tohkaku-johkitoh and keishi-bukuryo-gan showed remarkable inhibitory effects on fibrinolysis, coagulation and platelet aggregation. Tohki-shakuyaku-san showed distinct acceleration on fibrinolysis and strong inhibition on coagulation and platelet aggregation. It was, therefore, suggested that the anti-"oketsu"drugs had a clear possibility to affect the blood coagulation-fibrinolysis system. In twelve crude drugs, Rhei Rhizoma (dai-oh) had the strongest inhibitory effects on fibrinolysis and coagulation. However, it has become apparent that these effects were ascribed to the protein contents. Five crude drugs except Paeoniae Radix (shakuyaku) in tohki-shakuyaku-san formula were proved to accelerate fibrinolysis in vitro.