Objective To improve the GC-MS study of 2,6-butylated hydroxytoluene (BHT) by reasonable pretreatment of sample extracted from food plastic packaging materials. Methods Samples were extracted with hexane under ultrasound assisted extraction, stored for 2 d under 10 ℃, and analyzed by GC-MS after centrifugation and concentration. Results Total ion chromatograms of BHT GC-MS peak was clean, and impurity peak was significantly reduced. Conclusion The pre-treatment method could significantly improve the GC-MS study of 2,6-butylated hydroxytoluene (BHT).