Periostin and Ischemic Heart Disease

Periostin is an extracellular matrix protein.The mRNA and protein levels of periostin were strongly upregulated after vascular injury,and participate with smooth muscle cell differentiation and migration.Periostin was highly expressed in the myocardium after myocardial infarction and contributed to wound healing and scarring.In addition,periostin was involved in the process of myocarium hypertrophy and interstitial remodeling in heart failure.Periostin play an important role in pathophysiology of cardiovascular remodeling after injury and may be a new target of ischemic heart disease.This article reviewed the relationship between periostin and ischemic heart disease.