Anticonvulsion action of edulinine

Edulinine is a kind of alkaloid from the root of Zanthoxylum si mulans Hance. This natural constituent has been synthesized artificially. Experimental results have shown that the synthetic compound has marked anticonvulsion effect of MES on mice and rats by ip or ig administration. Edulinine can prevent convulsion induced by sodium glutamate, metrazol and TSZ. But it dosn't have evident effect onthe convulsion induced by picrotoxin. Pre-treatment of reserpine edulinine can elevate anticonvulsive ED50 of in mice. It is considered that edulinine has a strong anti convulsion efficiency which may be associated with some transmitters in the brain.