The advances in research on animal model of diabetic nephropathy

Diabetic nephropathy(DN) is one of the main complications of diabetes,it has become the leading cause of end stage renal failure,the pathogenesis of DN has not been completely clarified so far.Thus,it is important to establish ideal animal models of DN for pathogenesis investigation,generating treatment strategy,new drugs research and development,et al.Thus,we reviewed diabetic nephropathy models,and compared the advantages and disadvantages of the models from some aspects,such as modeling methods,pathogenesis,pathological changes and conditions of application.The new clues can be provided to apply appropriate animal models for research of diabetic nephropathy.