JAK1 somatic mutation in a myeloproliferative neoplasm

The Janus Kinase/Signal Transducer and Activator of Transcription (JAK/STAT) pathway plays a key oncogenic role in blood cancers, particularly myeloproliferative neoplasms (MPNs) and acute lymphoblastic leukemia (ALL). In normal cells, cytokine-induced activation of the JAK/STAT pathway stimulates