Skeletal Editing of Indazoles and Benzisoxazoles

Indazoles and benzisoxazoles, two eminent nitrogen-containing heterocyclic scaffolds, have attracted tremendous attention for diverse biological activities, involving antibacterial, anticancer, antiviral, antitumor, and antibiotic studies. On the other hand, a proficient tool for inserting, exchanging, or deleting atom within the core structure of the molecules, is described as skeletal editing, which is also a hot topic in recent days. Therefore, the skeletal modification of N-heterocycles facilitates many challenging synthetic pathways into simplified synthetic strategies for several medicinally important biochemicals. In general, the skeletal editing of these heterocycles proceeds through carbon insertion, nitrogen insertion and C-N bond insertion. This review article provides an overview of an eminent synthetic strategy, skeletal editing, of two noteworthy widespread heterocyclic compounds with literature coverage up to June, 2025.